Genetic changes in the HECT ubiquitin ligase HUWE1 are associated with intellectual disability, but it remains unknown whether HUWE1 functions in post-mitotic neurons to affect circuit function.Using genetics, pharmacology, and electrophysiology, we show that EEL-1, the HUWE1 ortholog in C.elegans, preferentially regulates GABAergic presynaptic tra
Webcams Background: We have applied in vivo two-dimensional (2D) localized correlation spectroscopy (2D L-COSY), in treated relapsing relapsing-remitting multiple sclerosis (RRMS) to identify novel biomarkers in normal-appearing brain parenchyma.Methods: 2D L-COSY magnetic resonance spectroscopy (MRS) spectra were prospectively acquired from the po
Since ancient times, honeybee drone pupae have been used Arm Chair as food and for medicinal purposes in Asia, the United States, and Europe.Honeybee (Apis mellifera L.) drone pupae have been registered as food ingredients in Korea.This material is promising as an alternative food source.It has carbohydrates, fats, and proteins, and contains variou
Radioadaptive response (RAR) describes a phenomenon in a variety of in vitro and in vivo systems that a low-dose of priming ionizing radiation (IR) reduces detrimental effects of a subsequent challenge IR at higher doses.Among in vivo investigations, studies using the mouse RAR model (Yonezawa Effect) showed that RAR could Outdoors significantly ex
High-impact river floods are often caused by very extreme precipitation events with return periods of several decades or centuries, and the design of flood protection measures thus relies on reliable estimates of the corresponding return values.However, calculating such return values from observations is associated with large statistical uncertaint