The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development
Genetic changes in the HECT ubiquitin ligase HUWE1 are associated with intellectual disability, but it remains unknown whether HUWE1 functions in post-mitotic neurons to affect circuit function.Using genetics, pharmacology, and electrophysiology, we show that EEL-1, the HUWE1 ortholog in C.elegans, preferentially regulates GABAergic presynaptic tra